From the abstract: "Our findings reveal a novel mechanism for Tip60 mediated sleep-wake regulation ... and provide insight into epigenetic-based regulation of sleep disturbances observed in neurodegenerative diseases like Alzheimer's disease."
Pirooznia SK, Chiu K, Chan MT, Zimmerman JE, Elefant F. Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep. Genetics. 2012 Dec;192(4):1327-45. PMID: 22982579; PMCID: PMC3512142.
See also this post on a related paper from the same lab group.