Not all fly models of disease start with a genetic mutation or disruption. Some start with a treatment or nutritional change--in this case, a high-sugar diet.
Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, Cagan R. A Drosophila model of high sugar diet-induced cardiomyopathy. PLoS Genet. 2013;9(1):e1003175. PMID: 23326243; PMCID: PMC3542070.
From the abstract: "Our data establish Drosophila as a useful system for exploring specific aspects of diet-induced heart dysfunction and emphasize enzymes within the hexosamine biosynthetic pathway as candidate therapeutic targets."
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