From the abstract: "Our results provide new insights ... and offer new therapeutic strategies for diseases involving PAR-1/MARK deregulation."
Lee S, Wang JW, Yu W, Lu B. Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila. Nat Commun. 2012;3:1312. PMID: 23271647.