Thursday, June 6, 2013

Fly models & Alzheimers disease. Regulation of PAR-1. Recent report.

From the abstract:  "Our results provide new insights ... and offer new therapeutic strategies for diseases involving PAR-1/MARK deregulation."

Lee S, Wang JW, Yu W, Lu B. Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila. Nat Commun. 2012;3:1312. PMID: 23271647.

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