Wednesday, June 12, 2013

Retinal degeneration/dystrophy & the fly. Recent report.

Lee J, Song M, Hong S. Negative Regulation of the Novel norpA(P24) Suppressor, diehard4, in the Endo-lysosomal Trafficking Underlies Photoreceptor Cell Degeneration. PLoS Genet. 2013 un;9(6):e1003559. Epub 2013 Jun 6. PMID: 23754968.

From the abstract:  "Our results demonstrate the existence of negative regulation in vesicular traffic between endosomes and lysosomes. We anticipate that the identification of additional components and an in-depth description of this specific molecular machinery will aid in therapeutic interventions of various retinal dystrophies and GPCR-related human diseases."

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