Wednesday, August 13, 2014

Fly models of Parkinson's disease--two new reports

Chen AY, Wilburn P, Hao X, Tully T. Walking Deficits and Centrophobism in an Alpha-Synuclein Fly Model of Parkinson's Disease. Genes Brain Behav. 2014 Aug 12. PMID: 25113870. [NOTE: As of this posting (8/13/14), the PubMed ID brings up an error message.]

Miura E, Hasegawa T, Konno M, Suzuki M, Sugeno N, Fujikake N, Geisler S, Tabuchi M, Oshima R, Kikuchi A, Baba T, Wada K, Nagai Y, Takeda A, Aoki M. VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease. Neurobiol Dis. 2014 Aug 6. pii: S0969-9961(14)00215-0. PMID: 25107340.

From the abstract: "Mutations in vacuolar protein sorting 35 (VPS35) have been linked to familial Parkinson's disease (PD). ... we found that the knockdown of Drosophila VPS35 not only induced the accumulation of the detergent-insoluble αSYN species in the brain but also exacerbated both locomotor impairments and mild compound eye disorganization and interommatidial bristle loss in flies expressing human αSYN. ..."

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