Wednesday, August 13, 2014

Review--mitochondria and Parkinson's Disease--drawing on results from many species including Drosophila

Haelterman NA, Yoon WH, Sandoval H, Jaiswal M, Shulman JM, Bellen HJ. A mitocentric view of Parkinson's disease. Annu Rev Neurosci. 2014 Jul 8;37:137-59. PMID: 24821430.

From the abstract: "... Here, we attempt to synthesize results from experimental studies in diverse systems to define the precise function of these PD genes, as well as their interplay with other genes that affect mitochondrial function. We propose that subtle mitochondrial defects in combination with other insults trigger the onset and progression of disease, in both familial and idiopathic PD."

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