Review--Hippo signal transduction pathway in disease

Barron DA, Kagey JD. The role of the Hippo pathway in human disease and tumorigenesis. Clin Transl Med. 2014 Jul 18;3:25. PMID: 25097728.

From the abstract: "The molecular nature of this pathway was first uncovered in Drosophila melanogaster ... The pathway is strongly conserved in humans, rendering Drosophila a suitable and efficient model system to better understand the molecular nature of this pathway. In the present study, we review the current understanding of the molecular mechanism and clinical impact of the Hippo pathway. ... Importantly, deregulated Hippo signaling is frequently observed in human cancers. ..."