New reports--fly models of neurodegenerative diseases

Catching up on neurodegenerative disease-related reports

Fly study related to ALS

Romano G, Klima R, Buratti E, Verstreken P, Baralle FE, Feiguin F. Chronological requirements of TDP-43 function in synaptic organization and locomotive control. Neurobiol Dis. 2014 Aug 1. pii: S0969-9961(14)00201-0. PMID: 25088713.

Mouse study follows up on potential therapeutic approach to HD identified in Drosophila

Arribat Y, Talmat-Amar Y, Paucard A, Lesport P, Bonneaud N, Bauer C, Bec N, Parmentier ML, Benigno L, Larroque C, Maurel P, Maschat F. Systemic delivery of P42 peptide: a new weapon to fight Huntington's disease. Acta Neuropathol Commun. 2014 Aug 5;2(1):86. PMID: 25091984.

Fly study related to frontotemporal dementia and ALS

Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IO, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, Hendrich O, Fratta P, Fisher EM, Partridge L, Isaacs AM. C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science. 2014 Aug 7. pii: 1256800. PMID: 25103406.

BMP signaling & neurodegenerative diseases

Kang MJ, Hansen TJ, Mickiewicz M, Kaczynski TJ, Fye S, Gunawardena S. Disruption of Axonal Transport Perturbs Bone Morphogenetic Protein (BMP) - Signaling and Contributes to Synaptic Abnormalities in Two Neurodegenerative Diseases. PLoS One. 2014 Aug 15;9(8):e104617. PMID: 25127478; PMCID: PMC4134223.

Primary fly larval neuron culture system for study of Alzheimer's disease

Saad Y, Segal D, Ayali A. Enhanced Neurite Outgrowth and Branching Precede Increased Amyloid-β-Induced Neuronal Apoptosis in a Novel Alzheimer's Disease Model. J Alzheimers Dis. 2014 Aug 14. PMID:  25125474

Review and reports related to Parkinson's disease

Chen KF, Crowther DC. Insights into amyloid disease from fly models. Essays Biochem. 2014 Aug 18;56(1):69-83. PMID: 25131587.

Varga SJ, Qi C, Podolsky E, Lee D. A new Drosophila model to study the interaction between genetic and environmental factors in Parkinson׳s disease. Brain Res. 2014 Aug 15. pii: S0006-8993(14)01085-3. PMID: 25130663.

Kimura Y, Fukushi J, Hori S, Matsuda N, Okatsu K, Kakiyama Y, Kawawaki J, Kakizuka A, Tanaka K. Different dynamic movements of wild-type and pathogenic VCPs and their cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system. Genes Cells. 2013 Dec;18(12):1131-43. PMID: 24215292.